pathogenesis
含义: The biological mechanism by which a disease develops and progresses. It describes the step-by-step process from initial cause to full clinical manifestation.
Pathogenesis is distinct from aetiology: while aetiology identifies the cause, pathogenesis explains how that cause produces disease at the cellular and molecular level. Understanding pathogenesis is critical for developing targeted therapies and predicting disease outcomes. The term is central to pathology, immunology, and pharmacology.
例句
- The pathogenesis of rheumatoid arthritis involves an autoimmune attack on the synovial membrane. 类风湿性关节炎的发病机制涉及对滑膜的自身免疫攻击。La patogénesis de la artritis reumatoide implica un ataque autoinmune contra la membrana sinovial.関節リウマチの病因機序は、滑膜に対する自己免疫攻撃を伴う。류마티스 관절염의 병인기전은 활막에 대한 자가면역 공격을 수반한다.
- Researchers mapped the pathogenesis of the virus from initial mucosal invasion to systemic spread. 研究人员绘制了该病毒从最初的粘膜侵入到全身扩散的发病机制图谱。Los investigadores cartografiaron la patogénesis del virus desde la invasión mucosa inicial hasta la diseminación sistémica.研究者たちは、そのウイルスの最初の粘膜侵入から全身性拡散に至るまでの病因機序を明らかにした。연구자들은 바이러스의 최초 점막 침입에서 전신 확산에 이르기까지의 병인기전을 규명하였다.
- A clearer understanding of the pathogenesis of sepsis has led to more effective treatment protocols. 对脓毒症发病机制更清晰的理解促成了更有效的治疗方案。Una comprensión más clara de la patogénesis de la sepsis ha dado lugar a protocolos de tratamiento más eficaces.敗血症の病因機序に対するより明確な理解が、より効果的な治療プロトコルにつながった。패혈증의 병인기전에 대한 보다 명확한 이해가 더욱 효과적인 치료 프로토콜로 이어졌다.
发音
用法指南
语境: medical, academic
语气: neutral
起源与历史
From Greek pathos meaning 'suffering' or 'disease' and genesis meaning 'origin' or 'creation.' The compound has been used in medical writing since the mid-19th century.
文化背景
Era: Modern
Generation: All ages
Social background: Universal
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